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Auditing the Editor: A Review of Key Translational Issues in Epigenetic Editing

Huerne, Katherine; Palmour, Nicole; Wu, Angela Ruohao; Beck, Stephan; Berner, Alison; Siebert, Reiner; Joly, Yann; (2022) Auditing the Editor: A Review of Key Translational Issues in Epigenetic Editing. The CRISPR Journal 10.1089/crispr.2021.0094. Green open access

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Abstract

Currently, most advances in site-specific epigenetic editing for human use are concentrated in basic research, yet, there is considerable interest to translate this technology beyond the bench. This review highlights recent developments with epigenetic editing technology in comparison with the canonical CRISPR-Cas genome editing, as well as the epistemic and ethical considerations with preemptive translation of epigenetic editing into clinical or commercial use in humans. Key considerations in safety, equity, and access to epigenetic editing are highlighted, with a spotlight on the ethical, legal, and social issues of this technology in the context of global health equity.

Type: Article
Title: Auditing the Editor: A Review of Key Translational Issues in Epigenetic Editing
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1089/crispr.2021.0094
Publisher version: https://doi.org/10.1089/crispr.2021.0094
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Cancer Bio
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
URI: https://discovery.ucl.ac.uk/id/eprint/10146611
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