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Radiologically isolated aquaporin-4 antibody neuromyelitis optica spectrum disorder

Abdel-Mannan, Omar; Klein, Ainat; Bachar Zipori, Anat; Ben-Sira, Liat; Fattal-Valevski, Aviva; Hacohen, Yael; Meirson, Hadas; (2022) Radiologically isolated aquaporin-4 antibody neuromyelitis optica spectrum disorder. Multiple Sclerosis Journal , 28 (4) pp. 676-679. 10.1177/13524585221074947. Green open access

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Abstract

Aquaporin-4 antibody (AQP4-Ab) Neuromyelitis Optica Spectrum Disorder (NMOSD) is a rare neuroinflammatory syndrome presenting predominantly with optic neuritis and transverse myelitis. We report a case of radiologically isolated longitudinally extensive optic neuritis in an asymptomatic 12-year-old female with positive serum AQP4-Ab, with resolution of imaging changes after immune therapy. By contrast to patients with radiologically isolated syndrome, of which some will never convert to multiple sclerosis, the pathogenicity of AQP4-Ab in the context of sub-clinical disease, supported treatment in our patient. Given the severe morbidity in AQP4-Ab NMOSD, prognostic biomarkers for disease severity are required to guide optimal therapy for patients.

Type: Article
Title: Radiologically isolated aquaporin-4 antibody neuromyelitis optica spectrum disorder
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/13524585221074947
Publisher version: https://doi.org/10.1177%2F13524585221074947
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Neuromyelitis optica spectrum disorder, aquaporin-4 antibody, paediatric demyelination, radiologically isolated syndrome
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
URI: https://discovery.ucl.ac.uk/id/eprint/10146503
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