UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Research Review: A guide to computing and implementing polygenic scores in developmental research

Allegrini, Andrea G; Baldwin, Jessie R; Barkhuizen, Wikus; Pingault, Jean-Baptiste; (2022) Research Review: A guide to computing and implementing polygenic scores in developmental research. Journal of Child Psychology and Psychiatry 10.1111/jcpp.13611. (In press). Green open access

[thumbnail of Baldwin_Research Review  A guide to computing and implementing polygenic scores in.pdf]
Preview
PDF
Baldwin_Research Review A guide to computing and implementing polygenic scores in.pdf - Published Version

Download (894kB) | Preview

Abstract

The increasing availability of genotype data in longitudinal population- and family-based samples provides opportunities for using polygenic scores (PGS) to study developmental questions in child and adolescent psychology and psychiatry. Here, we aim to provide a comprehensive overview of how PGS can be generated and implemented in developmental psycho(patho)logy, with a focus on longitudinal designs. As such, the paper is organized into three parts: First, we provide a formal definition of polygenic scores and related concepts, focusing on assumptions and limitations. Second, we give a general overview of the methods used to compute polygenic scores, ranging from the classic approach to more advanced methods. We include recommendations and reference resources available to researchers aiming to conduct PGS analyses. Finally, we focus on the practical applications of PGS in the analysis of longitudinal data. We describe how PGS have been used to research developmental outcomes, and how they can be applied to longitudinal data to address developmental questions.

Type: Article
Title: Research Review: A guide to computing and implementing polygenic scores in developmental research
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/jcpp.13611
Publisher version: https://doi.org/10.1111/jcpp.13611
Language: English
Additional information: © 2022 The Authors. Journal of Child Psychology and Psychiatry published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Keywords: Polygenic scores, developmental research, longitudinal models
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/10146479
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item