Schofield, Christine;
Chaudhuri, K Ray;
Carroll, Camille;
Sharma, Jagdish C;
Pavese, Nicola;
Evans, Jonathan;
Foltynie, Thomas;
... Lees, Andrew; + view all
(2022)
Opicapone in UK clinical practice: effectiveness, safety and cost analysis in patients with Parkinson's disease.
Neurodegenerative Disease Management
10.2217/nmt-2021-0057.
(In press).
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Abstract
AIM: This subanalysis of the OPTIPARK study aimed to confirm the effectiveness and safety of opicapone in patients with Parkinson's disease and motor fluctuations in clinical practice specifically in the UK and to assess the impact of opicapone on treatment costs. METHODS: Patients received opicapone added to levodopa for 6 months. Clinical outcomes were assessed at 3 and 6 months and treatment costs at 6 months. RESULTS: Most patients' general condition improved at 3 months, with sustained improvements reported at 6 months. Opicapone improved motor and non-motor symptoms at both timepoints, was generally well tolerated and reduced total treatment costs by GBP 3719. CONCLUSION: Opicapone added to levodopa resulted in clinical improvements and reduced treatment costs across UK clinical practice.
| Type: | Article |
|---|---|
| Title: | Opicapone in UK clinical practice: effectiveness, safety and cost analysis in patients with Parkinson's disease |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.2217/nmt-2021-0057 |
| Publisher version: | https://doi.org/10.2217/nmt-2021-0057 |
| Language: | English |
| Additional information: | © 2022 Future Science Group. This work is licensed under the Creative Commons Attribution4.0 License. To view a copy of this license, visit (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Parkinson's disease, cost-saving, health economics, levodopa, motor fluctuations, opicapone |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10146443 |
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