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Segmental and descending control of primary afferent input to the spinal lamina X

Krotov, Volodymyr; Agashkov, Kirill; Krasniakova, Marharyta; Safronov, Boris V; Belan, Pavel; Voitenko, Nana; (2022) Segmental and descending control of primary afferent input to the spinal lamina X. Pain 10.1097/j.pain.0000000000002597. Green open access

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Abstract

Despite being involved in a number of functions, such as nociception and locomotion, spinal lamina X remains one of the least studied central nervous system regions. Here, we show that Aδ- and C-afferent inputs to lamina X neurons are presynaptically inhibited by homo- and heterosegmental afferents as well as by descending fibers from the corticospinal tract, dorsolateral funiculus, and anterior funiculus. Activation of descending tracts suppresses primary afferent-evoked action potentials and also elicits excitatory (mono- and polysynaptic) and inhibitory postsynaptic responses in lamina X neurons. Thus, primary afferent input to lamina X is subject to both spinal and supraspinal control being regulated by at least 5 distinct pathways.

Type: Article
Title: Segmental and descending control of primary afferent input to the spinal lamina X
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1097/j.pain.0000000000002597
Publisher version: https://doi.org/10.1097/j.pain.0000000000002597
Language: English
Additional information: This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CC BY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
Keywords: spinal cord; lamina X; primary afferents; nociception; segmental control; descending, regulation; presynaptic inhibition; dorsolateral funiculus; anterior funiculus; corticospinal tract
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
URI: https://discovery.ucl.ac.uk/id/eprint/10146130
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