Meulmeester, Fleur L;
Luo, Jiao;
Martens, Leon G;
Ashrafi, Nadia;
de Mutsert, Renee;
Mook-Kanamori, Dennis O;
Lamb, Hildo J;
... Noordam, Raymond; + view all
(2021)
Association of measures of body fat with serum alpha-tocopherol and its metabolites in middle-aged individuals.
Nutrition, Metabolism & Cardiovascular Diseases
, 31
(8)
pp. 2407-2415.
10.1016/j.numecd.2021.05.001.
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Abstract
BACKGROUND AND AIMS: The accumulation of fat increases the formation of lipid peroxides, which are partly scavenged by alpha-tocopherol (α-TOH). Here, we aimed to investigate the associations between different measures of (abdominal) fat and levels of urinary α-TOH metabolites in middle-aged individuals. METHODS AND RESULTS: In this cross-sectional analysis in the Netherlands Epidemiology of Obesity study (N = 511, 53% women; mean [SD] age of 55 [6.1] years), serum α-TOH and α-TOH metabolites from 24-h urine were measured as alpha-tocopheronolactone hydroquinone (α-TLHQ, oxidized) and alpha-carboxymethyl-hydroxychroman (α-CEHC, enzymatically converted) using liquid-chromatography-tandem mass spectrometry. Body mass index and total body fat were measured, and abdominal subcutaneous and visceral adipose tissue (aSAT and VAT) were assessed using magnetic resonance imaging. Using multivariable-adjusted linear regression analyses, we analysed the associations of BMI, TBF, aSAT and VAT with levels of urinary α-TOH metabolites, adjusted for confounders. We observed no evidence for associations between body fat measures and serum α-TOH. Higher BMI and TBF were associated with lower urinary levels of TLHQ (0.95 [95%CI: 0.90, 1.00] and 0.94 [0.88, 1.01] times per SD, respectively) and with lower TLHQ relative to CEHC (0.93 [0.90, 0.98] and 0.93 [0.87, 0.98] times per SD, respectively). We observed similar associations for VAT (TLHQ: 0.94 [0.89, 0.99] times per SD), but not for aSAT. CONCLUSIONS: Opposite to our research hypothesis, higher abdominal adiposity was moderately associated with lower levels of oxidized α-TOH metabolites, which might reflect lower vitamin E antioxidative activity in individuals with higher abdominal fat instead.
| Type: | Article |
|---|---|
| Title: | Association of measures of body fat with serum alpha-tocopherol and its metabolites in middle-aged individuals |
| Location: | Netherlands |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.numecd.2021.05.001 |
| Publisher version: | https://doi.org/10.1016/j.numecd.2021.05.001 |
| Language: | English |
| Additional information: | © 2021 The Author(s). Published by Elsevier B.V. on behalf of The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. This is an open access article under the CC BY license (http://creativecommons. org/licenses/by/4.0/). |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Cardiac & Cardiovascular Systems, Endocrinology & Metabolism, Nutrition & Dietetics, Cardiovascular System & Cardiology, Obesity, Visceral adipose tissue, Subcutaneous adipose tissue, Vitamin E metabolites, Alpha tocopherol, Mass spectrometry, Epidemiology, OXIDATIVE STRESS, VITAMIN-E, OBESITY, EXPRESSION, PALMITATE, ADULTS, ACIDS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Genetics and Genomic Medicine Dept UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10146106 |
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