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Vesicular dysfunction and pathways to neurodegeneration

Lewis, Patrick A; (2021) Vesicular dysfunction and pathways to neurodegeneration. Essays in Biochemistry , 65 (7) pp. 941-948. 10.1042/EBC20210034. Green open access

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Abstract

Cellular control of vesicle biology and trafficking is critical for cell viability, with disruption of these pathways within the cells of the central nervous system resulting in neurodegeneration and disease. The past two decades have provided important insights into both the genetic and biological links between vesicle trafficking and neurodegeneration. In this essay, the pathways that have emerged as being critical for neuronal survival in the human brain will be discussed – illustrating the diversity of proteins and cellular events with three molecular case studies drawn from different neurological diseases.

Type: Article
Title: Vesicular dysfunction and pathways to neurodegeneration
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1042/EBC20210034
Publisher version: https://doi.org/10.1042/EBC20210034
Language: English
Additional information: © 2021 The Author(s). This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).
Keywords: axonal transport, endocytosis, mitophagy, neurodegeneration, trafficking
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
URI: https://discovery.ucl.ac.uk/id/eprint/10145795
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