Smethurst, Phillip;
Franklin, Hannah;
Clarke, Benjamin E;
Sidle, Katie;
Patani, Rickie;
(2022)
The role of astrocytes in prion-like mechanisms of neurodegeneration.
Brain
, Article awab366. 10.1093/brain/awab366.
(In press).
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Abstract
Accumulating evidence suggests that neurodegenerative diseases are not merely neuronal in nature but comprise multicellular involvement, with astrocytes emerging as key players. The pathomechanisms of several neurodegenerative diseases involve the deposition of misfolded protein aggregates in neurons that have characteristic prion-like behaviours such as template-directed seeding, intercellular propagation, distinct conformational strains and protein-mediated toxicity. The role of astrocytes in dealing with these pathological prion-like protein aggregates and whether their responses either protect from or conspire with the disease process is currently unclear. Here we review the existing literature implicating astrocytes in multiple neurodegenerative proteinopathies with a focus on prion-like behaviour in this context.
| Type: | Article |
|---|---|
| Title: | The role of astrocytes in prion-like mechanisms of neurodegeneration |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/brain/awab366 |
| Publisher version: | https://doi.org/10.1093/brain/awab366 |
| Language: | English |
| Additional information: | © The Author(s) (2022). Published by Oxford University Press on behalf of the Guarantors of Brain. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Astrocytes, prion-like, Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10145675 |
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