UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Cumulative incidence and risk factors for radiation induced leukoencephalopathy in high grade glioma long term survivors

Terziev, R; Psimaras, D; Marie, Y; Feuvret, L; Berzero, G; Jacob, J; Dehais, C; ... Ricard, D; + view all (2021) Cumulative incidence and risk factors for radiation induced leukoencephalopathy in high grade glioma long term survivors. Scientific Reports , 11 (1) , Article 10176. 10.1038/s41598-021-89216-1. Green open access

[thumbnail of Kinnersley_s41598-021-89216-1.pdf]
Preview
Text
Kinnersley_s41598-021-89216-1.pdf - Published Version

Download (945kB) | Preview

Abstract

The incidence and risk factors associated with radiation-induced leukoencephalopathy (RIL) in long-term survivors of high-grade glioma (HGG) are still poorly investigated. We performed a retrospective research in our institutional database for patients with supratentorial HGG treated with focal radiotherapy, having a progression-free overall survival > 30 months and available germline DNA. We reviewed MRI scans for signs of leukoencephalopathy on T2/FLAIR sequences, and medical records for information on cerebrovascular risk factors and neurological symptoms. We investigated a panel of candidate single nucleotide polymorphisms (SNPs) to assess genetic risk. Eighty-one HGG patients (18 grade IV and 63 grade III, 50M/31F) were included in the study. The median age at the time of radiotherapy was 48 years old (range 18–69). The median follow-up after the completion of radiotherapy was 79 months. A total of 44 patients (44/81, 54.3%) developed RIL during follow-up. Twenty-nine of the 44 patients developed consistent symptoms such as subcortical dementia (n = 28), gait disturbances (n = 12), and urinary incontinence (n = 9). The cumulative incidence of RIL was 21% at 12 months, 42% at 36 months, and 48% at 60 months. Age > 60 years, smoking, and the germline SNP rs2120825 (PPARg locus) were associated with an increased risk of RIL. Our study identified potential risk factors for the development of RIL (age, smoking, and the germline SNP rs2120825) and established the rationale for testing PPARg agonists in the prevention and management of late-delayed radiation-induced neurotoxicity.

Type: Article
Title: Cumulative incidence and risk factors for radiation induced leukoencephalopathy in high grade glioma long term survivors
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41598-021-89216-1
Publisher version: https://doi.org/10.1038/s41598-021-89216-1
Language: English
Additional information: © 2022 Springer Nature Limited. This article is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/).
Keywords: Cancer therapy, CNS cancer, Molecular medicine, Neurotoxicity syndromes, Oncology, Radiotherapy, Risk factors, White matter disease
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
URI: https://discovery.ucl.ac.uk/id/eprint/10145638
Downloads since deposit
18Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item