Clift, Ashley Kieran;
Coupland, Carol AC;
Keogh, Ruth H;
Hemingway, Harry;
Hippisley-Cox, Julia;
(2021)
COVID-19 Mortality Risk in Down Syndrome: Results From a Cohort Study Of 8 Million Adults.
Annals of Internal Medicine
, 174
(4)
pp. 572-576.
10.7326/M20-4986.
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Abstract
Background: At the start of the coronavirus disease 2019 (COVID-19) pandemic, many national health organizations emphasized nonpharmacologic interventions, such as quarantining or physical distancing. In the United Kingdom, strict self-isolation (“shielding”) was advised for those deemed to be clinically extremely vulnerable on the basis of the presence of selected medical conditions or at the discretion of their general practitioners. Down syndrome features on neither the U.K. shielding list nor the U.S. Centers for Disease Control and Prevention list of groups at “increased risk.” However, it is associated with immune dysfunction, congenital heart disease, and pulmonary pathology and, given its prevalence, may be a relevant albeit unconfirmed risk factor for severe COVID-19
Type: | Article |
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Title: | COVID-19 Mortality Risk in Down Syndrome: Results From a Cohort Study Of 8 Million Adults |
Location: | United States |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.7326/M20-4986 |
Publisher version: | https://doi.org/10.7326/M20-4986 |
Language: | English |
Additional information: | © 2020 American College of Physicians. Some rights reserved. This work permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited. |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences |
URI: | https://discovery.ucl.ac.uk/id/eprint/10145551 |
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