UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Identification of prodromal presentations of Parkinson's disease among primary care outpatients in Germany

Bohlken, J; Schrag, A; Riedel-Heller, S; Kostev, K; (2022) Identification of prodromal presentations of Parkinson's disease among primary care outpatients in Germany. Neuroepidemiology , 56 (1) pp. 41-49. 10.1159/000520574. Green open access

[thumbnail of Schrag_Parkinson 2021 .pdf]
Preview
PDF
Schrag_Parkinson 2021 .pdf - Accepted Version

Download (361kB) | Preview

Abstract

Background: This study aimed to identify clinical features that predate the diagnosis of PD in a primary care setting. Methods: This retrospective case-control study was based on data from the Disease Analyzer database (IQVIA) and included 17,702 patients with Parkinson's disease and 17,702 non-PD controls matched for age, sex, and index year. We analyzed the prevalence of 15 defined diagnoses and symptoms documented within 2 years, ≥2 to <5, and ≥5 to <10 years prior to the index date in patients with and without PD. Logistic regression analyses were conducted to assess the association between PD and the predefined diagnoses. Results: The prevalence of motor, neuropsychiatric and autonomic features was higher in those with a later diagnosis of Parkinson's disease than controls for all three periods except for rigidity in the ≥2 to <5 and ≥5 to <10-year periods and erectile dysfunction in the most recent period before diagnosis. The clinical presentation recorded in the greatest percentage of patients was depression, followed by dizziness, insomnia, and constipation, but these were also common in the control population. The odds ratios were highest for increase in tremor, followed by balance impairment and memory problems, particularly in the latest period before diagnosis, and by constipation particularly in the earliest period examined. Conclusion: The prodromal features of PD could be identified in this large primary care database in Germany with similar results to those found in previous database studies despite differences in methodologies and systems.

Type: Article
Title: Identification of prodromal presentations of Parkinson's disease among primary care outpatients in Germany
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.1159/000520574
Publisher version: https://doi.org/10.1159/000520574
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Case-control study, General practice, Germany, Parkinson’s disease, Prodromal features
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
URI: https://discovery.ucl.ac.uk/id/eprint/10145416
Downloads since deposit
193Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item