Alfano, Lindsay N;
Focht Garand, Kendrea L;
Malandraki, Georgia A;
Salam, Sharfaraz;
Machado, Pedro M;
Dimachkie, Mazen M;
(2022)
Measuring change in inclusion body myositis: clinical assessments versus imaging.
Clinical and Experimental Rheumatology
, 40
(2)
pp. 404-413.
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Abstract
Sporadic inclusion body myositis (sIBM) is a heterogeneous progressive inflammatory muscle disease impacting skeletal muscles in the head, neck, and limbs. Use of valid, reliable, sensitive, and standardised clinical and paraclinical outcome assessments (COA) are critical to inform both proactive clinical care and clinical trial design. Here we review clinical and imaging methods used to quantify muscle strength, size, or function in sIBM, and discuss their application to clinical practice and use in clinical trials. Considerations for future work to validate measures in this population are also discussed.
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