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Blue Skies research is essential for ending the Tuberculosis pandemic and advancing a personalized medicine approach for holistic management of Respiratory Tract infections

Ntoumi, Francine; Petersen, Eskild; Mwaba, Peter; Aklillu, Eleni; Mfinanga, Sayoki; Yeboah-Manu, Dorothy; Maeurer, Markus; (2022) Blue Skies research is essential for ending the Tuberculosis pandemic and advancing a personalized medicine approach for holistic management of Respiratory Tract infections. International Journal of Infectious Diseases 10.1016/j.ijid.2022.03.012. (In press). Green open access

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Abstract

Objectives: Investments into ‘blue skies’ fundamental TB research in low- and middle-income countries (LMICs) have not been forthcoming. We highlight why blue skies research will be essential for achieving global TB control and eradicating TB. // Methods: We review the historical background to early TB discovery research and give examples of where investments into basic science and fundamental ‘blue skies research’ are delivering novel data and approaches to advance diagnosis, management and holistic care for patients with active and latent TB infection. // Findings: The COVID-19 pandemic has shown that making available adequate funding for priority investments into ‘Blue skies research’ to delineate scientific understanding of a new infectious diseases threat to global health security can lead to rapid development and rollout of new diagnostic platforms, treatments, and vaccines. Several advances in new TB diagnostics, new treatments and vaccine development are underpinned by basic science research. // Conclusions: Basic science research focused can pave the way for a personalized medicine approach for management of TB and other Respiratory Tract Infections and preventing long-term functional disability. Transfer of skills and resources by wealthier nations is required to empower researchers in LMICs countries to engage in and lead basic science ‘blue skies research.

Type: Article
Title: Blue Skies research is essential for ending the Tuberculosis pandemic and advancing a personalized medicine approach for holistic management of Respiratory Tract infections
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ijid.2022.03.012
Publisher version: https://doi.org/10.1016/j.ijid.2022.03.012
Language: English
Additional information: © 2022 Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0)
Keywords: tuberculosis; Research; basic science; fundamental; blue skies research
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10145371
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