Martins, D;
Brodmann, K;
Veronese, M;
Dipasquale, O;
Mazibuko, N;
Schuschnig, U;
Zelaya, F;
... Paloyelis, Y; + view all
(2022)
“Less is more”: A dose-response account of intranasal oxytocin pharmacodynamics in the human brain.
Progress in Neurobiology
, 211
, Article 102239. 10.1016/j.pneurobio.2022.102239.
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Abstract
Intranasal oxytocin is attracting attention as a potential treatment for several brain disorders due to promising preclinical results. However, translating findings to humans has been hampered by remaining uncertainties about its pharmacodynamics and the methods used to probe its effects in the human brain. Using a dose-response design (9, 18 and 36 IU), we demonstrate that intranasal oxytocin-induced changes in local regional cerebral blood flow (rCBF) in the amygdala at rest, and in the covariance between rCBF in the amygdala and other key hubs of the brain oxytocin system, follow a dose-response curve with maximal effects for lower doses. Yet, the effects on local rCBF might vary by amygdala subdivision, highlighting the need to qualify dose-response curves within subregion. We further link physiological changes with the density of the oxytocin receptor gene mRNA across brain regions, strengthening our confidence in intranasal oxytocin as a valid approach to engage central targets. Finally, we demonstrate that intranasal oxytocin does not disrupt cerebrovascular reactivity, which corroborates the validity of haemodynamic neuroimaging to probe the effects of intranasal oxytocin in the human brain. Data availability: Participants did not consent for open sharing of the data. Therefore, data can only be accessed from the corresponding author upon reasonable request
| Type: | Article |
|---|---|
| Title: | “Less is more”: A dose-response account of intranasal oxytocin pharmacodynamics in the human brain |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.pneurobio.2022.102239 |
| Publisher version: | https://doi.org/10.1016/j.pneurobio.2022.102239 |
| Language: | English |
| Additional information: | © 2022 The Author(s). Published by Elsevier Ltd. under a Creative Commons license (https://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Allen Brain Atlas, Cerebrovascular reactivity, Dose-response, Intranasal oxytocin, Nebulizer, Regional cerebral blood flow |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10145219 |
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