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Neuronal Activity Regulates Hippocampal miRNA Expression

Eacker, Stephen M; Keuss, Matthew J; Berezikov, Eugene; Dawson, Valina L; Dawson, Ted M; (2011) Neuronal Activity Regulates Hippocampal miRNA Expression. PLoS ONE , 6 (10) , Article e25068. 10.1371/journal.pone.0025068. Green open access

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Abstract

euronal activity regulates a broad range of processes in the hippocampus, including the precise regulation of translation. Disruptions in proper translational control in the nervous system are associated with a variety of disorders that fall in the autistic spectrum. MicroRNA (miRNA) represent a relatively recently discovered player in the regulation of translation in the nervous system. We have conducted an in depth analysis of how neuronal activity regulates miRNA expression in the hippocampus. Using deep sequencing we exhaustively identify all miRNAs, including 15 novel miRNAs, expressed in hippocampus of the adult mouse. We identified 119 miRNAs documented in miRBase but less than half of these miRNA were expressed at a level greater than 0.1% of total miRNA. Expression profiling following induction of neuronal activity by electroconvulsive shock demonstrates that most miRNA show a biphasic pattern of expression: rapid induction of specific mature miRNA expression followed by a decline in expression. These results have important implications into how miRNAs influence activity-dependent translational control.

Type: Article
Title: Neuronal Activity Regulates Hippocampal miRNA Expression
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0025068
Publisher version: https://doi.org/10.1371/journal.pone.0025068
Language: English
Additional information: © 2011 Eacker et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/).
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
URI: https://discovery.ucl.ac.uk/id/eprint/10145081
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