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Stability and context of intercalated motifs (i-motifs) for biological applications

Irving, Kelly L; King, Jessica J; Waller, Zoë AE; Evans, Cameron W; Smith, Nicole M; (2022) Stability and context of intercalated motifs (i-motifs) for biological applications. Biochimie 10.1016/j.biochi.2022.03.001. (In press).

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Abstract

DNA is naturally dynamic and can self-assemble into alternative secondary structures including the intercalated motif (i-motif), a four-stranded structure formed in cytosine-rich DNA sequences. Until recently, i-motifs were thought to be unstable in physiological cellular environments. Studies demonstrating their existence in the human genome and role in gene regulation are now shining light on their biological relevance. Herein, we review the effects of epigenetic modifications on i-motif structure and stability, and biological factors that affect i-motif formation within cells. Furthermore, we highlight recent progress in targeting i-motifs with structure-specific ligands for biotechnology and therapeutic purposes.

Type: Article
Title: Stability and context of intercalated motifs (i-motifs) for biological applications
Location: France
DOI: 10.1016/j.biochi.2022.03.001
Publisher version: https://doi.org/10.1016/j.biochi.2022.03.001
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Cytosine, i-motif, DNA structure, Ligands, Methylation, Proteins
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
URI: https://discovery.ucl.ac.uk/id/eprint/10144974
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