Chowdhury, Rafat;
Papoutsaki, Marianthi-Vasiliki;
Muller, Christoph A;
Smith, Lorna;
Gong, Fiona;
Bullock, Max;
Rogers, Harriet;
... Punwani, Shonit; + view all
(2022)
A reproducible dynamic phantom for sequence testing in hyperpolarised ¹³C-magnetic resonance.
British Journal of Radiology
, 95
(1134)
, Article 20210770. 10.1259/bjr.20210770.
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Abstract
OBJECTIVES: To develop a phantom system which can be integrated with an automated injection system, eliminating the experimental variability that arises with manual injection; for the purposes of pulse sequence testing and metric derivation in hyperpolarised 13C-MR. METHODS: The custom dynamic phantom was machined from Ultem and filled with an NADH and LDH mixture dissolved in phosphate buffered saline. Hyperpolarised [1-13C]-pyruvate was then injected into the phantom (n = 8) via an automated syringe pump and the conversion of pyruvate to lactate monitored through a 13C imaging sequence. RESULTS: The phantom showed low coefficient of variation for the lactate to pyruvate peak signal heights (11.6%) and dynamic area-under curve ratios (11.0%). The variance for the LDH enzyme rate constant (kP) was also seen to be low at 15.6%. CONCLUSION: The dynamic phantom demonstrates high reproducibility for quantification of 13C-hyperpolarised MR derived metrics. Establishing such a phantom is needed to facilitate development of hyperpolarsed 13C-MR pulse sequenced; and moreover, to enable multi site hyperpolarised 13C-MR clinical trials where assessment of metric variability across sites is critical. ADVANCES IN KNOWLEDGE: The dynamic phantom developed during the course of this study will be a useful tool in testing new pulse sequences and standardisation in future hyperpolarised work.
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