UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Minds and Brains, Sleep and Psychiatry

Hobson, J Allan; Gott, Jarrod A; Friston, Karl J; (2021) Minds and Brains, Sleep and Psychiatry. Psychiatric Research and Clinical Practice , 3 (1) pp. 12-28. 10.1176/appi.prcp.20200023. Green open access

[thumbnail of Psych Res and Clin Practice - 2020.pdf]
Preview
Text
Psych Res and Clin Practice - 2020.pdf - Published Version

Download (990kB) | Preview

Abstract

OBJECTIVE: This article offers a philosophical thesis for psychiatric disorders that rests upon some simple truths about the mind and brain. Specifically, it asks whether the dual aspect monism—that emerges from sleep research and theoretical neurobiology—can be applied to pathophysiology and psychopathology in psychiatry. METHODS: Our starting point is that the mind and brain are emergent aspects of the same (neuronal) dynamics; namely, the brain–mind. Our endpoint is that synaptic dysconnection syndromes inherit the same dual aspect; namely, aberrant inference or belief updating on the one hand, and a failure of neuromodulatory synaptic gain control on the other. We start with some basic considerations from sleep research that integrate the phenomenology of dreaming with the neurophysiology of sleep. RESULTS: We then leverage this treatment by treating the brain as an organ of inference. Our particular focus is on the role of precision (i.e., the representation of uncertainty) in belief updating and the accompanying synaptic mechanisms. CONCLUSIONS: Finally, we suggest a dual aspect approach—based upon belief updating (i.e., mind processes) and its neurophysiological implementation (i.e., brain processes)—has a wide explanatory compass for psychiatry and various movement disorders. This approach identifies the kind of pathophysiology that underwrites psychopathology—and points to certain psychotherapeutic and psychopharmacological targets, which may stand in mechanistic relation to each other.

Type: Article
Title: Minds and Brains, Sleep and Psychiatry
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1176/appi.prcp.20200023
Publisher version: https://doi.org/10.1176/appi.prcp.20200023
Language: English
Additional information: © 2020 The Authors. Psychiatric Research and Clinical Practice published by Wiley Periodicals, LLC on behalf of the American Psychiatric Association. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
URI: https://discovery.ucl.ac.uk/id/eprint/10144628
Downloads since deposit
27Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item