Zhang, Yue;
(2022)
Investigation of single-needle and multi- needle electrohydrodynamic processes for the preparation of drug loaded particles.
Doctoral thesis (Ph.D), UCL (University College London).
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Abstract
In recent years, polymeric products of micro-/nano dimensions have attracted considerable attention, and complex structures have been demonstrated to be generated from solid and encapsulated particles/fibres. Although various approaches have been developed to make these products, the bioactive agents are poorly controlled and bio-stable due to the drawbacks such as high costs of processing and the requirement for non-biocompatible solvents and additives. In contrast, electrohydrodynamic atomization (EHDA) and co-axial EHDA (CEHDA) processes are simple and has been extensively studied as a popular technology for producing and processing micro-/nanostructured materials containing bioactive molecules. The simplicity, flexibility of EHDA experimental setup, and efficiency of generating particulate materials at the micro-/nanoscale, with controllable size, shape, and morphology, make electrospraying to become one of the most fascinating tools to be employed in pharmaceutics, food, and healthcare fields. The first objective of this research was to see how different physical and mechanical processing parameters affected the encapsulated particles manufactured by the EHDA method. The second objective of this work was to encapsulate progesterone into polymer matrix using single needle EHDA system, and further improving aqueous solubility and sustained release of progesterone by varying Poly (D,L lactide-co-glicolide acid) (PLGA) copolymer composition and polymer:drug ratio. The third objective of this study was to use a CEHDA system to prepare and investigate the release of progesterone from core-shell nanoparticles. The fourth objective was to use an CEHDA system incorporating a tri-axial capillary device to fabricate multidrug (saxagliptin and dapagliflozin) loaded triple-layered biodegradable nanoparticles for the potential treatment of type 2 diabetes. The last objective was to prepare multidrug loaded double-layered and uniform structured nanoparticles and compare the drug release profiles between different particle configurations. This work reveals a powerful approach for producing micro and nano drug-loaded polymeric particles with modified release behaviour and improved physiological solubility and bioavailability of poorly water-soluble drugs by fulfilling these goals.
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | Ph.D |
| Title: | Investigation of single-needle and multi- needle electrohydrodynamic processes for the preparation of drug loaded particles |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| Additional information: | Copyright © The Author 2021. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Licence (https://creativecommons.org/licenses/by-nc/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request. |
| UCL classification: | UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering UCL > Provost and Vice Provost Offices > UCL BEAMS UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10144589 |
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