Arnaldo, Irene;
Corcoran, Andrew W;
Friston, Karl J;
Ramstead, Maxwell JD;
(2022)
Stress and its sequelae: An active inference account of the etiological pathway from allostatic overload to depression.
Neuroscience & Biobehavioral Reviews
, 135
, Article 104590. 10.1016/j.neubiorev.2022.104590.
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Abstract
Survival requires the implementation of adaptive changes that demand energy resources. The efficient regulation of energetic resources thus plays a critical role in enabling systems to adapt to the demands of their internal and external environments. The framework of active inference explains how living organisms can build probabilistic models that enable them to predict, track, and regulate energy expenditure in the short and long run. The aim of the paper is to characterize the physiological changes that accompany stress, and the relationship between these changes and the loss of confidence in a system's predictions about its internal and external milieu-ultimately manifesting as depressive symptomatology. We identify the systems that underwrite goal-directed behavior, and the neuroendocrine and immunological systems, as the hierarchical controller that regulates energy resources. In doing so, we establish an etiological pathway from allostatic overload to depression via active inference.
| Type: | Article |
|---|---|
| Title: | Stress and its sequelae: An active inference account of the etiological pathway from allostatic overload to depression |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.neubiorev.2022.104590 |
| Publisher version: | https://doi.org/10.1016/j.neubiorev.2022.104590 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Active inference, Allostasis, Allostatic load, Depression, Inflammation, Stress |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10144556 |
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