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Positive psychological constructs and association with reduced risk of mild cognitive impairment and dementia in older adults: a systematic review and meta-analysis

Bell, Georgia; Singham, Timothy; Saunders, Rob; John, Amber; Stott, Joshua; (2022) Positive psychological constructs and association with reduced risk of mild cognitive impairment and dementia in older adults: a systematic review and meta-analysis. Ageing Research Reviews , Article 101594. 10.1016/j.arr.2022.101594. (In press).

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Abstract

Understanding factors associated with dementia risk is important for informing future interventions aimed at dementia prevention. There is accumulating evidence for the association between depression and risk of dementia, however less is known about the association between positive psychological factors and dementia incidence. This review aims to synthesise evidence regarding the association between positive psychological constructs (PPCs) and later risk of MCI and dementia in adults aged 50 and over. Literature searches were conducted in Medline, PsycINFO, and Scopus until March 2021. Papers reporting on the association between at least one PPC and later risk of MCI or dementia in people aged 50+ without cognitive impairment at baseline were included. Results from the meta-analyses revealed that purpose in life was significantly associated with a reduced risk of dementia (HR = 0.81, 95% CI [0.78, 0.85], p <.001), however results for positive affect were non-significant (HR = 0.94, 95% CI [0.76, 1.15], p =.54). Results for other PPCs are described narratively. Mixed findings for different PPCs highlight the importance of investigating these factors individually. Understanding which factors may play a protective role in their association with risk of mild cognitive impairment and dementia could have important implications for informing dementia prevention interventions.

Type: Article
Title: Positive psychological constructs and association with reduced risk of mild cognitive impairment and dementia in older adults: a systematic review and meta-analysis
Location: England
DOI: 10.1016/j.arr.2022.101594
Publisher version: https://doi.org/10.1016/j.arr.2022.101594
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Dementia, Meta-Analysis, Mild cognitive impairment, Positive psychology, Systematic review
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/10144523
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