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Interaction of Mitochondrial Calcium and ROS in Neurodegeneration

Baev, Artyom Y; Vinokurov, Andrey Y; Novikova, Irina N; Dremin, Viktor V; Potapova, Elena V; Abramov, Andrey Y; (2022) Interaction of Mitochondrial Calcium and ROS in Neurodegeneration. Cells , 11 (4) , Article 706. 10.3390/cells11040706. Green open access

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Abstract

Neurodegenerative disorders are currently incurable devastating diseases which are characterized by the slow and progressive loss of neurons in specific brain regions. Progress in the investigation of the mechanisms of these disorders helped to identify a number of genes associated with familial forms of these diseases and a number of toxins and risk factors which trigger sporadic and toxic forms of these diseases. Recently, some similarities in the mechanisms of neurodegenerative diseases were identified, including the involvement of mitochondria, oxidative stress, and the abnormality of Ca2+ signaling in neurons and astrocytes. Thus, mitochondria produce reactive oxygen species during metabolism which play a further role in redox signaling, but this may also act as an additional trigger for abnormal mitochondrial calcium handling, resulting in mitochondrial calcium overload. Combinations of these factors can be the trigger of neuronal cell death in some pathologies. Here, we review the latest literature on the crosstalk of reactive oxygen species and Ca2+ in brain mitochondria in physiology and beyond, considering how changes in mitochondrial metabolism or redox signaling can convert this interaction into a pathological event.

Type: Article
Title: Interaction of Mitochondrial Calcium and ROS in Neurodegeneration
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/cells11040706
Publisher version: https://doi.org/10.3390/cells11040706
Language: English
Additional information: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: neurodegeneration; mitochondria; calcium; reactive oxygen species; cell death; permeability transition pore; neuron
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
URI: https://discovery.ucl.ac.uk/id/eprint/10144432
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