di Martino, Erica;
Smith, Lesley;
Bradley, Stephen H;
Hemphill, Scott;
Wright, Judy;
Renzi, Cristina;
Bergin, Rebecca;
... Neal, Richard D; + view all
(2022)
Incidence trends for twelve cancers in younger adults—a rapid review.
British Journal of Cancer
10.1038/s41416-022-01704-x.
(In press).
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Abstract
Many cancer referral guidelines use patient's age as a key criterium to decide who should be referred urgently. A recent rise in the incidence of colorectal cancer in younger adults has been described in high-income countries worldwide. Information on other cancers is more limited. The aim of this rapid review was to determine whether other cancers are also increasing in younger age groups, as this may have important implications for prioritising patients for investigation and referral. We searched MEDLINE, Embase and Web of Science for studies describing age-related incidence trends for colorectal, bladder, lung, oesophagus, pancreas, stomach, breast, ovarian, uterine, kidney and laryngeal cancer and myeloma. 'Younger' patients were defined based on NICE guidelines for cancer referral. Ninety-eight studies met the inclusion criteria. Findings show that the incidence of colorectal, breast, kidney, pancreas, uterine cancer is increasing in younger age groups, whilst the incidence of lung, laryngeal and bladder cancer is decreasing. Data for oesophageal, stomach, ovarian cancer and myeloma were inconclusive. Overall, this review provides evidence that some cancers are increasingly being diagnosed in younger age groups, although the mechanisms remain unclear. Cancer investigation and referral guidelines may need updating in light of these trends.
| Type: | Article |
|---|---|
| Title: | Incidence trends for twelve cancers in younger adults—a rapid review |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41416-022-01704-x |
| Publisher version: | https://doi.org/10.1038/s41416-022-01704-x |
| Language: | English |
| Additional information: | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Oncology, NONCARDIA GASTRIC-CANCER, RENAL-CELL CARCINOMA, AGE-SPECIFIC TRENDS, BREAST-CANCER, COLORECTAL-CANCER, UNITED-STATES, INCREASING INCIDENCE, INCIDENCE RATES, HISTOLOGIC SUBTYPE, MORTALITY TRENDS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Behavioural Science and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10144096 |
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