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Advancing bacteriophages as a treatment of antibiotic-resistant bacterial pulmonary infections

Satta, Giovanni; O’Callaghan, Christopher; Clokie, Martha RJ; Di Luca, Mariagrazia; (2022) Advancing bacteriophages as a treatment of antibiotic-resistant bacterial pulmonary infections. Current Opinion in Pulmonary Medicine 10.1097/mcp.0000000000000864. (In press).

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Abstract

Purpose of review: The current article summarizes the recent advances in the use of bacteriophages to treat pulmonary infections, particularly those caused by Gram-negative drug-resistant bacteria, including Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae and Burkholderia species. It provides an updated overview of the current available evidence, with a summary of published clinical cases, case series and clinical trials currently underway. Recent finding: Personalized treatment with bacteriophages is still in its infancy in Europe and the USA, despite extensive experience in Eastern countries. However, more patients are expected to be treated with clinical trials in progress and others planned. Summary: Despite very promising initial results and the confirmation of phage safety, there are still many ethical and practical implications to be considered, from the necessary regulatory approval to optimization of dose and route of administration, to developing strategies to tackle bacterial resistance. Patients with cystic fibrosis are a group where phage therapy, if successful, could have a major impact.

Type: Article
Title: Advancing bacteriophages as a treatment of antibiotic-resistant bacterial pulmonary infections
DOI: 10.1097/mcp.0000000000000864
Publisher version: https://doi.org/10.1097/MCP.0000000000000864
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10143926
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