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Advances in systemic lupus erythematosus

Abida, R; Yeoh, SA; Isenberg, DA; (2022) Advances in systemic lupus erythematosus. Medicine , 50 (1) pp. 7-17. 10.1016/j.mpmed.2021.10.003. Green open access

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Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a heterogeneous course and systemic involvement. It is the result of a complex pathogenic pathway that culminates in autoantibody formation. The interaction between environmental triggers and genetic susceptibility is key in this process. Genome-wide association study technology has allowed the recognition of >80 loci associated with SLE that lead to the formation of key proteins, each contributing a small increase to the risk. Advances in the management of the disease include new validated standardized tools to capture disease activity, damage and quality of life, for clinical and research purposes. The prognosis of SLE has much improved in the last 50 years because of better general management and specific treatment, including better use of immunosuppressive agents and development of a new group of drugs – biologic therapies.

Type: Article
Title: Advances in systemic lupus erythematosus
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.mpmed.2021.10.003
Publisher version: https://doi.org/10.1016/j.mpmed.2021.10.003
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Disease activity index, management, MRCP, pathogenesis, systemic lupus erythematosus, treatment
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10143880
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