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Dopamine enhances model-free credit assignment through boosting of retrospective model-based inference

Deserno, L; Moran, R; Michely, J; Lee, Y; Dayan, P; Dolan, RJ; (2021) Dopamine enhances model-free credit assignment through boosting of retrospective model-based inference. eLife , 10 , Article e67778. 10.7554/eLife.67778. Green open access

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Abstract

Dopamine is implicated in representing model-free (MF) reward prediction errors a as well as influencing model-based (MB) credit assignment and choice. Putative cooperative interactions between MB and MF systems include a guidance of MF credit assignment by MB inference. Here, we used a double-blind, placebo-controlled, within-subjects design to test an hypothesis that enhancing dopamine levels boosts the guidance of MF credit assignment by MB inference. In line with this, we found that levodopa enhanced guidance of MF credit assignment by MB inference, without impacting MF and MB influences directly. This drug effect correlated negatively with a dopaminedependent change in purely MB credit assignment, possibly reflecting a trade-off between these two MB components of behavioural control. Our findings of a dopamine boost in MB inference guidance of MF learning highlights a novel DA influence on MB-MF cooperative interactions.

Type: Article
Title: Dopamine enhances model-free credit assignment through boosting of retrospective model-based inference
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.7554/eLife.67778
Publisher version: https://doi.org/10.7554/eLife.67778
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: dopamine, human, model-free/model-based, neuroscience, reinforcement learning, Adult, Dopamine, Double-Blind Method, Female, Humans, Learning, Male, Models, Psychological, Reinforcement, Psychology, Reward, Young Adult
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
URI: https://discovery.ucl.ac.uk/id/eprint/10143591
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