Jiang, Jian;
Ju, Jun;
Luo, Liang;
Song, Ze;
Liao, Huanquan;
Yang, Xiuyan;
Wei, Shoupeng;
... Li, Ningning; + view all
(2022)
Salmon Calcitonin Exerts an Antidepressant Effect by Activating Amylin Receptors.
Frontiers in Pharmacology
, 13
, Article 826055. 10.3389/fphar.2022.826055.
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Abstract
Depressive disorder is defined as a psychiatric disease characterized by the core symptoms of anhedonia and learned helplessness. Currently, the treatment of depression still calls for medications with high effectiveness, rapid action, and few side effects, although many drugs, including fluoxetine and ketamine, have been approved for clinical usage by the Food and Drug Administration (FDA). In this study, we focused on calcitonin as an amylin receptor polypeptide, of which the antidepressant effect has not been reported, even if calcitonin gene-related peptides have been previously demonstrated to improve depressive-like behaviors in rodents. Here, the antidepressant potential of salmon calcitonin (sCT) was first evaluated in a chronic restraint stress (CRS) mouse model of depression. We observed that the immobility duration in CRS mice was significantly increased during the tail suspension test and forced swimming test. Furthermore, a single administration of sCT was found to successfully rescue depressive-like behaviors in CRS mice. Lastly, AC187 as a potent amylin receptor antagonist was applied to investigate the roles of amylin receptors in depression. We found that AC187 significantly eliminated the antidepressant effects of sCT. Taken together, our data revealed that sCT could ameliorate a depressive-like phenotype probably via the amylin signaling pathway. sCT should be considered as a potential therapeutic candidate for depressive disorder in the future.
| Type: | Article |
|---|---|
| Title: | Salmon Calcitonin Exerts an Antidepressant Effect by Activating Amylin Receptors |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fphar.2022.826055 |
| Publisher version: | https://doi.org/10.3389/fphar.2022.826055 |
| Language: | English |
| Additional information: | Copyright © 2022 Jiang, Ju, Luo, Song, Liao, Yang, Wei, Wang, Zhu, Chang, Ma, Hu, Yu, Wang, Hou, Li, Li and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | behavior test, depression, salmon calcitonin, chronic restraint stress, amylin receptor, AC187 |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10143549 |
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