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Invasive Dental Treatment and Acute Vascular Events: A Systematic Review and Meta-Analysis

Luthra, Shailly; Orlandi, Marco; Leira, Yago; Bokre, Desta; Marletta, Debora; Rotundo, Roberto; Harden, Simon; (2022) Invasive Dental Treatment and Acute Vascular Events: A Systematic Review and Meta-Analysis. Journal of Clinical Periodontology , 49 (5) pp. 467-479. 10.1111/jcpe.13600. Green open access

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Abstract

BACKGROUND: Acute infection/inflammation increases the risk of acute vascular events. Invasive dental treatments (IDT) trigger short-term acute inflammation. PURPOSE: To critically appraise the evidence linking IDT and acute vascular events. DATA SOURCES: Six bibliographical databases were searched up to 31st August 2021. A systematic review following PRISMA guidelines was performed. STUDY SELECTION: Intervention and observational studies reporting any acute vascular events following IDT. DATA EXTRACTION: Two reviewers independently extracted data and rated the quality of studies. Data was pooled using fixed effect, inverse variance weights analysis. RISK OF BIAS: Newcastle-Ottawa Quality Assessment Scale for observational studies and the Cochrane Handbook -Rob 2.0 for randomised controlled trials. DATA SYNTHESIS: Three out of 16 clinical studies, a total of 533,175 participants, 124,344 myocardial infarctions and of 327,804 ischemic strokes were reported. Meta-analysis confirmed that IDT did not increase incidence ratios (IR) for combined vascular events either at 1-4 weeks (IR of 1.02, 95% CIs: 0.92, 1.13) and at 5-8 weeks (IR of 1.04, 95% CIs-0.97;1.10) after treatment. LIMITATIONS: High level of heterogeneity (study designs and timepoint assessments). CONCLUSIONS: Patients who received IDT exhibited no substantial increase in vascular risk over 8 weeks post treatment.

Type: Article
Title: Invasive Dental Treatment and Acute Vascular Events: A Systematic Review and Meta-Analysis
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/jcpe.13600
Publisher version: https://doi.org/10.1111/jcpe.13600
Language: English
Additional information: © 2022 The Authors. Journal of Clinical Periodontology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Keywords: cardiovascular diseases, dental treatment, extraction, inflammation, periodontitis
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Restorative Dental Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > VP: Research > Library Services
URI: https://discovery.ucl.ac.uk/id/eprint/10143537
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