Luthra, Shailly;
Orlandi, Marco;
Leira, Yago;
Bokre, Desta;
Marletta, Debora;
Rotundo, Roberto;
Harden, Simon;
(2022)
Invasive Dental Treatment and Acute Vascular Events: A Systematic Review and Meta-Analysis.
Journal of Clinical Periodontology
, 49
(5)
pp. 467-479.
10.1111/jcpe.13600.
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D'Aiuto_J Clinic Periodontology - 2022 - Luthra - Invasive dental treatment and acute vascular events A systematic review and.pdf Download (2MB) | Preview |
Abstract
BACKGROUND: Acute infection/inflammation increases the risk of acute vascular events. Invasive dental treatments (IDT) trigger short-term acute inflammation. PURPOSE: To critically appraise the evidence linking IDT and acute vascular events. DATA SOURCES: Six bibliographical databases were searched up to 31st August 2021. A systematic review following PRISMA guidelines was performed. STUDY SELECTION: Intervention and observational studies reporting any acute vascular events following IDT. DATA EXTRACTION: Two reviewers independently extracted data and rated the quality of studies. Data was pooled using fixed effect, inverse variance weights analysis. RISK OF BIAS: Newcastle-Ottawa Quality Assessment Scale for observational studies and the Cochrane Handbook -Rob 2.0 for randomised controlled trials. DATA SYNTHESIS: Three out of 16 clinical studies, a total of 533,175 participants, 124,344 myocardial infarctions and of 327,804 ischemic strokes were reported. Meta-analysis confirmed that IDT did not increase incidence ratios (IR) for combined vascular events either at 1-4 weeks (IR of 1.02, 95% CIs: 0.92, 1.13) and at 5-8 weeks (IR of 1.04, 95% CIs-0.97;1.10) after treatment. LIMITATIONS: High level of heterogeneity (study designs and timepoint assessments). CONCLUSIONS: Patients who received IDT exhibited no substantial increase in vascular risk over 8 weeks post treatment.
| Type: | Article |
|---|---|
| Title: | Invasive Dental Treatment and Acute Vascular Events: A Systematic Review and Meta-Analysis |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/jcpe.13600 |
| Publisher version: | https://doi.org/10.1111/jcpe.13600 |
| Language: | English |
| Additional information: | © 2022 The Authors. Journal of Clinical Periodontology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
| Keywords: | cardiovascular diseases, dental treatment, extraction, inflammation, periodontitis |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Restorative Dental Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute UCL > Provost and Vice Provost Offices > VP: Research > Library Services |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10143537 |
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