Crum, James;
Zhang, Xian;
Noah, Adam;
Hamilton, Antonia;
Tachtsidis, Ilias;
Burgess, Paul;
Hirsch, Joy;
(2022)
An Approach to Neuroimaging Interpersonal Interactions in Mental Health Interventions.
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
, 7
(7)
pp. 669-679.
10.1016/j.bpsc.2022.01.008.
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Abstract
BACKGROUND: Conventional paradigms in clinical neuroscience tend to be constrained in terms of ecological validity, raising several challenges to studying the mechanisms mediating treatments and outcomes in clinical settings. Addressing these issues requires real-world neuroimaging techniques that are capable of continuously collecting data during free-flowing interpersonal interactions and that allow for experimental designs which are representative of the clinical situations in which they occur. METHODS: In this work, we developed a paradigm that fractionates the major components of the human-to-human verbal interactions occurring in clinical situations and used functional near-infrared spectroscopy to assess the brain systems underlying clinician-client discourse (n = 30). RESULTS: Cross-brain neural coupling between people was significantly greater during clinical interactions compared to everyday-life verbal communication, particularly between the prefrontal cortex (PFC) (e.g., inferior frontal gyrus) and inferior parietal lobule (e.g., supramarginal gyrus). Interestingly, the clinical tasks revealed extensive increases in activity across the PFC, especially in rostral PFC (area 10) during periods in which participants were required to silently reason about the dysfunctional cognitions of the other person. CONCLUSIONS: This work demonstrates a novel experimental approach to investigating the neural underpinnings of interpersonal interactions that typically occur in clinical settings, and its findings support the idea that particular prefrontal systems might be critical to cultivating mental health.
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