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Recent developments of neuroprotective agents for degenerative retinal disorders

Ou, Kepeng; Li, Youjian; Liu, Ling; Li, Hua; Cox, Katherine; Wu, Jiahui; Liu, Jian; (2022) Recent developments of neuroprotective agents for degenerative retinal disorders. Neural Regeneration Research , 17 (9) pp. 1919-1928. 10.4103/1673-5374.335140. Green open access

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Abstract

Retinal degeneration is a debilitating ocular complication characterized by the progressive loss of photoreceptors and other retinal neurons, which are caused by a group of retinal diseases affecting various age groups, and increasingly prevalent in the elderly. Age-related macular degeneration, diabetic retinopathy and glaucoma are among the most common complex degenerative retinal disorders, posing significant public health problems worldwide largely due to the aging society and the lack of effective therapeutics. Whilst pathoetiologies vary, if left untreated, loss of retinal neurons can result in an acquired degeneration and ultimately severe visual impairment. Irrespective of underlined etiology, loss of neurons and supporting cells including retinal pigment epithelium, microvascular endothelium, and glia, converges as the common endpoint of retinal degeneration and therefore discovery or repurposing of therapies to protect retinal neurons directly or indirectly are under intensive investigation. This review overviews recent developments of potential neuroprotectants including neuropeptides, exosomes, mitochondrial-derived peptides, complement inhibitors, senolytics, autophagy enhancers and antioxidants either still experimentally or in clinical trials. Effective treatments that possess direct or indirect neuroprotective properties would significantly lift the burden of visual handicap.

Type: Article
Title: Recent developments of neuroprotective agents for degenerative retinal disorders
Location: India
Open access status: An open access version is available from UCL Discovery
DOI: 10.4103/1673-5374.335140
Publisher version: https://doi.org/10.4103/1673-5374.335140
Language: English
Additional information: © Neural Regeneration Research 2022. This is an open access journal, and articles are distributed under the terms of the Creative Commons AttributionNonCommercial-ShareAlike 4.0 License (https://creativecommons.org/licenses/by-nc-sa/4.0/).
Keywords: antioxidants, autophagy enhancers, complement inhibitors, exosomes, neuropeptides, neuroprotective agents, retinal degeneration, senolytics
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10143448
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