Vargas, Jobert;
Sleigh, James;
Schiavo, Giampietro;
(2022)
Coupling axonal mRNA transport and local translation to organelle maintenance and function.
Current Opinion in Cell Biology
, 74
pp. 97-103.
10.1016/j.ceb.2022.01.008.
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Abstract
Neuronal homeostasis requires the transport of various organelles to distal compartments and defects in this process lead to neurological disorders. Although several mechanisms for the delivery of organelles to axons and dendrites have been elucidated, exactly how this process is orchestrated is not well-understood. In this review, we discuss the recent literature supporting a novel paradigm – the co-shuttling of mRNAs with different membrane-bound organelles. This model postulates that the tethering of ribonucleoprotein complexes to endolysosomes and mitochondria allows for the spatiotemporal coupling of organelle transport and the delivery of transcripts to axons. Subcellular translation of these “hitchhiking” transcripts may thus provide a proximal source of proteins required for the maintenance and function of organelles in axons.
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