UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Systemic adjuvant chemotherapy for advanced malignant ocular medulloepithelioma

Sheriff, Ibrahim HN; Karaa, Esin K; Chowdhury, Tanzina; Scheimberg, Irene; Duncan, Catriona; Reddy, M Ashwin; Sagoo, Mandeep S; (2022) Systemic adjuvant chemotherapy for advanced malignant ocular medulloepithelioma. Eye 10.1038/s41433-022-01936-4. (In press). Green open access

[thumbnail of Sagoo_Systemic adjuvant chemotherapy for advanced malignant ocular medulloepithelioma_VoR.pdf]
Preview
Text
Sagoo_Systemic adjuvant chemotherapy for advanced malignant ocular medulloepithelioma_VoR.pdf - Published Version

Download (823kB) | Preview

Abstract

BACKGROUND: Ocular medulloepithelioma (diktyoma) is a rare and potentially malignant paediatric tumour of the non-pigmented ciliary epithelium. Adjuvant chemotherapy can be given in advanced cases, but the indications and regimens remain to be defined. The aim was to identify whether adjuvant chemotherapy offers treatment benefit in advanced ocular medulloepithelioma. METHODS: This was a retrospective case series of subjects referred to a single specialist ocular oncology centre for advanced ocular medulloepithelioma subsequently treated with enucleation, including those needing adjuvant systemic vincristine, etoposide and carboplatin. A case-note review was performed for included subjects meeting referral criteria. The outcomes were histopathology characteristics, recurrence, metastases and survival. RESULTS: Between March 2010 and June 2017, four male patients (mean age 31 months) underwent enucleation for ocular medulloepithelioma. Adjuvant chemotherapy was commenced in 3 patients (75%) due to malignant histopathological features. With a mean follow-up time of 81.5 months (median 71 months, range 49-135 months) none of the patients have had recurrence, metastases or death from the tumour. CONCLUSIONS: This series is unique in reporting the management of advanced malignant ocular medulloepithelioma with adjuvant systemic vincristine, etoposide and carboplatin for advanced tumours with malignant features. This regimen appears to be safe and may be effective in preventing metastatic spread.

Type: Article
Title: Systemic adjuvant chemotherapy for advanced malignant ocular medulloepithelioma
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41433-022-01936-4
Publisher version: https://doi.org/10.1038/s41433-022-01936-4
Language: English
Additional information: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Keywords: Chemotherapy, Eye cancer
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10143136
Downloads since deposit
17Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item