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‘Case of the Month’ from the Specialist Centre for Kidney Cancer, Royal Free London Hospital, UK: 99mTc-sestamibi SPECT-CT to differentiate renal cell carcinoma from benign oncocytoma

Miller, Jonjo; Campain, Nicholas; Boydell, Anna-Rita; Warren, Hannah; Vito, Ivy; Neves, Joana; Mumtaz, Faiz; ... Tran, Maxine GB; + view all (2022) ‘Case of the Month’ from the Specialist Centre for Kidney Cancer, Royal Free London Hospital, UK: 99mTc-sestamibi SPECT-CT to differentiate renal cell carcinoma from benign oncocytoma. BJU International , 129 (1) pp. 28-31. 10.1111/bju.15652.

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Abstract

Our first patient (P1) is a 69-year-old male with a 4-year history of a progressively enlarging left renal upper pole mass; contrast-enhanced CT demonstrated a 3.4-cm lesion in 2017, increasing in size on sequential cross-sectional imaging to 6.0 cm as of March 2021. A renal tumour biopsy (RTB) was performed in 2020 when the tumour measured 5.6 cm and demonstrated cells in a solid nest and trabeculae pattern, with eosinophilic cytoplasm, hyperchromatic nuclei, and inconspicuous nucleoli. Immunohistochemistry was CD117, e-cadherin (incomplete) and CD10 positive, cytokeratin 7 and vimentin negative, consistent with a diagnosis of oncocytoma [1]. The {99}^mtechnetium ({99m}^Tc)-sestamibi single-photon emission CT (SPECT)-CT showed increased uptake within the tumour, consistent with the histological diagnosis of oncocytoma (Fig. 1). As the mass continues to enlarge, and the patient remains keen for non-surgical active treatment, cryotherapy is being considered as an alternative treatment option.

Type: Article
Title: ‘Case of the Month’ from the Specialist Centre for Kidney Cancer, Royal Free London Hospital, UK: 99mTc-sestamibi SPECT-CT to differentiate renal cell carcinoma from benign oncocytoma
Location: England
DOI: 10.1111/bju.15652
Publisher version: https://doi.org/10.1111/bju.15652
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
URI: https://discovery.ucl.ac.uk/id/eprint/10142956
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