Singh-Manoux, Archana;
Oumarou-Ibrahim, Amina;
Machado-Fragua, Marcos D;
Dumurgier, Julien;
Brunner, Erics J;
Kivimaki, Mika;
Fayosse, Aurore;
(2022)
Association between kidney function and incidence of dementia: 10-year follow-up of the Whitehall II cohort study.
Age Ageing
, 51
(1)
, Article afab259. 10.1093/ageing/afab259.
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Abstract
BACKGROUND: Cognitive dysfunction is common in haemodialysis patients but whether poor kidney function in the general population is also associated with higher risk of dementia remains unclear. OBJECTIVE: To examine the association of kidney function with incident dementia in community dwelling older adults. DESIGN: Whitehall II prospective study. SETTING: Population-based study on 6,050 adults, mean age 65.8 in 2007-2009. METHODS: Poor kidney function, defined as estimated Glomerular Filtration Rate (eGFR) <60 ml/min/1.73 m2 in 2007-2009, and adverse change in eGFR was defined as decrease ≥4 ml/min/1.73 m2 between 2007-2009 and 2012-2013.Incident dementia was ascertained through linkage to electronic health records, and Cox regression was used to examine associations with dementia. RESULTS: A total of 306 cases of dementia were recorded over a mean follow-up of 10 years. Baseline eGFR <60 was associated with a hazard ratio (HR) for dementia of 1.37 (95% CI 1.02, 1.85) in analysis adjusted for sociodemographic factors, hypertension, obesity, stroke, diabetes and cardiovascular disease/medication. Removing stroke cases at baseline and censoring them over the follow-up yielded an HR of 1.42 (95% CI 1.00, 2.00) for the association between CKD and dementia. Decline of eGFR ≥4 between 2007-2009 and 2012-2013 was associated with incidence of dementia over a 6.3 year mean follow-up (HR: 1.37; 95% CI 1.02, 1.85), with somewhat stronger associations when analyses were restricted to those with eGFR ≥60 in 2007-2009 (1.56; 95% CI: 1.12, 2.19). CONCLUSION: Poor and declining kidney function in older adults is associated with a higher risk of dementia that is not attributable to stroke and persists after accounting for major cardiometabolic conditions.
| Type: | Article |
|---|---|
| Title: | Association between kidney function and incidence of dementia: 10-year follow-up of the Whitehall II cohort study |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/ageing/afab259 |
| Publisher version: | https://doi.org/10.1093/ageing/afab259 |
| Language: | English |
| Additional information: | © The Author(s) 2021. Published by Oxford University Press on behalf of the British Geriatrics Society. This is an Open Access ar ticle distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | ageing, chronic kidney disease (CKD), cohort study, dementia, estimated Glomerular Filtration Rate (eGFR), older people |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10142847 |
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