UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Novel artful applications of vaccines at the horizon

Montin, Davide; Ottaviano, Giorgio; Sangerardi, Maria; Sgrulletti, Mayla; Chini, Loredana; Dellepiane, Rosa Maria; Martire, Baldassarre; ... Moschese, Viviana; + view all (2022) Novel artful applications of vaccines at the horizon. Pediatric Allergy and Immunology , 33 (S27) pp. 83-85. 10.1111/pai.13638. Green open access

[thumbnail of Ottaviano_Novel artful applications of vaccines at the horizon_VoR.pdf]
Preview
Text
Ottaviano_Novel artful applications of vaccines at the horizon_VoR.pdf - Published Version

Download (203kB) | Preview

Abstract

Some live vaccines, particularly Bacillus Calmette-Guérin (BCG), oral polio vaccine (OPV), and measles vaccine, can reduce the incidence of all-cause mortality by outreaching the mere control of specific infections and exerting off-target effects. Asides from the prevention of viral infection, some other vaccines, such as those against flu or rotavirus, could reduce the risk of developing autoimmunity. The nonspecific effects of vaccines are mediated by the innate immune system, mainly through the so-called trained innate immunity. These observations paved the way for developing tolerogenic and trained immunity-based vaccines with substantial implications for more effective use of vaccines and combat vaccine hesitancy.

Type: Article
Title: Novel artful applications of vaccines at the horizon
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/pai.13638
Publisher version: https://doi.org/10.1111/pai.13638
Language: English
Additional information: © 2022 The Authors. Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/).
Keywords: autoimmunity, BCG, diabetes, measles, mRNA vaccines, nonspecific effects, vaccines
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/10142754
Downloads since deposit
102Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item