Montin, Davide;
Ottaviano, Giorgio;
Sangerardi, Maria;
Sgrulletti, Mayla;
Chini, Loredana;
Dellepiane, Rosa Maria;
Martire, Baldassarre;
... Moschese, Viviana; + view all
(2022)
Novel artful applications of vaccines at the horizon.
Pediatric Allergy and Immunology
, 33
(S27)
pp. 83-85.
10.1111/pai.13638.
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Abstract
Some live vaccines, particularly Bacillus Calmette-Guérin (BCG), oral polio vaccine (OPV), and measles vaccine, can reduce the incidence of all-cause mortality by outreaching the mere control of specific infections and exerting off-target effects. Asides from the prevention of viral infection, some other vaccines, such as those against flu or rotavirus, could reduce the risk of developing autoimmunity. The nonspecific effects of vaccines are mediated by the innate immune system, mainly through the so-called trained innate immunity. These observations paved the way for developing tolerogenic and trained immunity-based vaccines with substantial implications for more effective use of vaccines and combat vaccine hesitancy.
| Type: | Article |
|---|---|
| Title: | Novel artful applications of vaccines at the horizon |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/pai.13638 |
| Publisher version: | https://doi.org/10.1111/pai.13638 |
| Language: | English |
| Additional information: | © 2022 The Authors. Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/). |
| Keywords: | autoimmunity, BCG, diabetes, measles, mRNA vaccines, nonspecific effects, vaccines |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10142754 |
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