Malik, Farihah;
Malyuta, Ruslan;
Volokha, Alla;
Bailey, Heather;
Collins, Intira Jeannie;
Thorne, Claire;
Ukraine Paediatric HIV Cohort;
(2022)
Hepatitis C Virus Treatment Response to Direct-acting Antivirals Among Adolescents With HIV/HCV Coinfection: Real-world Data From Ukraine.
The Pediatric Infectious Disease Journal
, 41
(5)
pp. 417-419.
10.1097/INF.0000000000003467.
Preview |
Text
Malik_Ukraine_DAAs_20210729_PIDJ_accepted_forRPS.pdf - Accepted Version Download (162kB) | Preview |
Abstract
Direct-acting antivirals (DAAs) have been approved for treating chronic hepatitis C virus (HCV) in children and adolescents. Although DAAs have been used in real-world settings for the treatment of HCV monoinfected adolescents, few reports of real-world use of DAAs in children and adolescents who are coinfected with human immunodeficiency virus (HIV) are available. We evaluated the real-world safety and effectiveness of DAAs in HIV/HCV coinfected adolescents from the Ukraine Paediatric HIV Cohort Study including all those for whom treatment outcomes were available by April 2021. Overall, 6 coinfected adolescents had received DAA treatment; 4 with sofosbuvir/ledipasvir (SOF/LDV), 1 with SOF/LDV+ribavirin, and 1 with SOF/daclatasvir. No patient discontinued treatment due to adverse events and no serious adverse events were reported. All 6 patients achieved sustained virologic response by 12 weeks after the end of therapy. DAA treatment was well tolerated and effective in adolescents with HIV/HCV coinfection in a real-world setting.
Archive Staff Only
 |
View Item |
