Robinson, George Anthony;
Wilkinson, Meredyth G Ll;
Wincup, Chris;
(2022)
The Role of Immunometabolism in the Pathogenesis of Systemic Lupus Erythematosus.
Frontiers in Immunology
, 12
, Article 806560. 10.3389/fimmu.2021.806560.
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Abstract
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder in which pathogenic abnormalities within both the innate and adaptive immune response have been described. In order to activated, proliferate and maintain this immunological response a drastic upregulation in energy metabolism is required. Recently, a greater understanding of these changes in cellular bioenergetics have provided new insight into the links between immune response and the pathogenesis of a number of diseases, ranging from cancer to diabetes and multiple sclerosis. In this review, we highlight the latest understanding of the role of immunometabolism in SLE with particular focus on the role of abnormal mitochondrial function, lipid metabolism, and mTOR signaling in the immunological phenomenon observed in the SLE. We also consider what implications this has for future therapeutic options in the management of the disease in future.
| Type: | Article |
|---|---|
| Title: | The Role of Immunometabolism in the Pathogenesis of Systemic Lupus Erythematosus |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fimmu.2021.806560 |
| Publisher version: | https://doi.org/10.3389/fimmu.2021.806560 |
| Language: | English |
| Additional information: | Copyright © 2022 Robinson, Wilkinson and Wincup. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | systemic lupus erythematosus (SLE), immunometabolism, mitochondria, lipid metabolism, T cell, B cell, monocyte, autoimmunity |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10142736 |
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