UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Thermal analysis of mammalian stratum corneum using differential scanning calorimetry for advancing skin research and drug delivery

Goh, CF; Hadgraft, J; Lane, ME; (2022) Thermal analysis of mammalian stratum corneum using differential scanning calorimetry for advancing skin research and drug delivery. International Journal of Pharmaceutics , 614 , Article 121447. 10.1016/j.ijpharm.2021.121447. Green open access

[thumbnail of Lane_Final manuscript IJP - revised.pdf]
Preview
Text
Lane_Final manuscript IJP - revised.pdf

Download (1MB) | Preview

Abstract

For effective topical and transdermal drug delivery, it is necessary for most actives to penetrate and permeate through the stratum corneum (SC). Extensive investigation of the thermal behaviour of mammalian SC has been performed to understand the barrier function of the skin. However, little attention has been paid to the related experimental variables in thermal analysis of the SC using differential scanning calorimetry that may influence the results obtained from such studies. In this review, we provide a comprehensive overview of the thermal transitions of the SC of both porcine and human skin. More importantly, the selection and impact of the experimental and instrumental parameters used in thermal analysis of the SC are critically evaluated. New opportunities for the use of thermal analysis of mammalian SC in advancing skin research, particularly for elucidation of the actions of excipients employed in topical and transdermal formulations on the skin are also highlighted.

Type: Article
Title: Thermal analysis of mammalian stratum corneum using differential scanning calorimetry for advancing skin research and drug delivery
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ijpharm.2021.121447
Publisher version: https://doi.org/10.1016/j.ijpharm.2021.121447
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Differential scanning calorimetry, Excipients, Keratin protein, Mammalian skin, Skin lipids, Skin permeation, Stratum corneum
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: https://discovery.ucl.ac.uk/id/eprint/10142568
Downloads since deposit
159Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item