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Novel Cellular Therapies for Hepatocellular Carcinoma

Roddy, H; Meyer, T; Roddie, C; (2022) Novel Cellular Therapies for Hepatocellular Carcinoma. Cancers , 14 (3) , Article 504. 10.3390/cancers14030504. Green open access

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Abstract

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer related death worldwide. Most patients present with advanced disease, and current gold-standard management using tyrosine kinase inhibitors or immune checkpoint inhibitors (ICIs) offers modest clinical benefit. Cellular immune therapies targeting HCC are currently being tested in the laboratory and in clinical trials. Here, we review the landscape of cellular immunotherapy for HCC, defining antigenic targets, outlining the range of cell therapy products being applied in HCC (such as CAR-T and TCR-T), and exploring how advanced engineering solutions may further enhance this therapeutic approach.

Type: Article
Title: Novel Cellular Therapies for Hepatocellular Carcinoma
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/cancers14030504
Publisher version: http://dx.doi.org/10.3390/cancers14030504
Language: English
Additional information: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: hepatocellular carcinoma; immunotherapy; chimeric antigen receptor (CAR) T-cells; engineered TCR T-cells
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/10142537
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