UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Graphene Nanoflake Antibody Conjugates for Multimodal Imaging of Tumors

Lamb, J; Šimaitis, J; Halukeerthi, SO; Salzmann, CG; Holland, JP; (2021) Graphene Nanoflake Antibody Conjugates for Multimodal Imaging of Tumors. Advanced NanoBiomed Research , 1 (9) , Article 2100009. 10.1002/anbr.202100009. Green open access

[thumbnail of Salzmann_Advanced NanoBiomed Research - 2021 - Lamb - Graphene Nanoflake Antibody Conjugates for Multimodal Imaging of Tumors.pdf]
Preview
Text
Salzmann_Advanced NanoBiomed Research - 2021 - Lamb - Graphene Nanoflake Antibody Conjugates for Multimodal Imaging of Tumors.pdf - Published Version

Download (2MB) | Preview

Abstract

Graphene-based materials are promising scaffolds for use in the design of tailored-made nanomedicines. Herein, the synthesis and characterization of a series of multifunctional carboxylated graphene nanoflakes (GNFs) conjugated to monoclonal antibodies (mAbs) for tumor-specific binding and modulation of pharmacokinetics is presented. GNF–mAb constructs are coupled to a fluorophore (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene [BODIPY]) for applications in optical imaging, a paramagnetic Gd3+ complex, [GdDOTAGA(H2O)]−, and the hexadentate chelate desferrioxamine B (DFO) for radiolabeling with 89Zr4+ (t1/2 = 78.41 h) ions and applications in dual-modality positron emission tomography/magnetic resonance imaging (PET/MRI). Experimental properties of [89Zr]GdDOTAGA–ZrDFO–GNF–trastuzumab are tested in extensive chemical, spectroscopic, radiochemical, and cellular assays in vitro, and assessment of the pharmacokinetics by PET imaging in mice bearing a human ovarian cancer model illustrates the potential of using GNF–mAbs to develop multifunctional PET/MRI probes.

Type: Article
Title: Graphene Nanoflake Antibody Conjugates for Multimodal Imaging of Tumors
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/anbr.202100009
Publisher version: https://doi.org/10.1002/anbr.202100009
Language: English
Additional information: Copyright © 2021 The Authors. Advanced NanoBiomed Research published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: antibodies, cancer, graphene, multimodal imaging, positron emission tomography
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/10142512
Downloads since deposit
21Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item