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Lipid metabolism in autoimmune rheumatic disease: implications for modern and conventional therapies

Robinson, G; Pineda-Torra, I; Ciurtin, C; Jury, EC; (2022) Lipid metabolism in autoimmune rheumatic disease: implications for modern and conventional therapies. Journal of Clinical Investigation , 132 (2) , Article e148552. 10.1172/JCI148552. Green open access

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Abstract

Suppressing inflammation has been the primary focus of therapies in autoimmune rheumatic diseases (AIRDs), including rheumatoid arthritis and systemic lupus erythematosus. However, conventional therapies with low target specificity can have effects on cell metabolism that are less predictable. A key example is lipid metabolism; current therapies can improve or exacerbate dyslipidemia. Many conventional drugs also require in vivo metabolism for their conversion into therapeutically beneficial products; however, drug metabolism often involves the additional formation of toxic by-products, and rates of drug metabolism can be heterogeneous between patients. New therapeutic technologies and research have highlighted alternative metabolic pathways that can be more specifically targeted to reduce inflammation but also to prevent undesirable off-target metabolic consequences of conventional antiinflammatory therapies. This Review highlights the role of lipid metabolism in inflammation and in the mechanisms of action of AIRD therapeutics. Opportunities for cotherapies targeting lipid metabolism that could reduce immunometabolic complications and potential increased cardiovascular disease risk in patients with AIRDs are discussed.

Type: Article
Title: Lipid metabolism in autoimmune rheumatic disease: implications for modern and conventional therapies
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1172/JCI148552
Publisher version: http://dx.doi.org/10.1172/JCI148552
Language: English
Additional information: Copyright: © 2022, Robinson et al. This is an open access article published under the terms of the Creative Commons Attribution 4.0 International License.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10142486
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