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Biomarker Testing for People With Advanced Lung Cancer in England

Adizie, JB; Tweedie, J; Khakwani, A; Peach, E; Hubbard, R; Wood, N; Gosney, JR; ... Navani, N; + view all (2021) Biomarker Testing for People With Advanced Lung Cancer in England. JTO Clinical and Research Reports , 2 (6) , Article 100176. 10.1016/j.jtocrr.2021.100176. Green open access

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Abstract

Introduction: Optimal management of people with advanced NSCLC depends on accurate identification of predictive markers. Yet, real-world data in this setting are limited. We describe the impact, timeliness, and outcomes of molecular testing for patients with advanced NSCLC and good performance status in England. // Methods: In collaboration with Public Health England, patients with stages IIIB to IV NSCLC, with an Eastern Cooperative Oncology Group performance status of 0 to 2, in England, between June 2017 and December 2017, were identified. All English hospitals were invited to record information. // Results: A total of 60 of 142 invited hospitals in England participated in this study and submitted data on 1157 patients. During the study period, 83% of patients with advanced adenocarcinoma underwent molecular testing for three recommended predictive biomarkers (EGFR, ALK, and programmed death-ligand 1). A total of 80% of patients with nonsquamous carcinomas on whom biomarker testing was performed had adequate tissue for analysis on initial sampling. First-line treatment with a tyrosine kinase inhibitor was received by 71% of patients with adenocarcinoma and a sensitizing EGFR mutation and by 59% of those with an ALK translocation. Of patients with no driver mutation and a programmed death-ligand 1 expression of greater than or equal to 50%, 47% received immunotherapy. // Conclusions: We present a comprehensive data set for molecular testing in England. Although molecular testing is well established in England, timeliness and uptake of targeted therapies should be improved.

Type: Article
Title: Biomarker Testing for People With Advanced Lung Cancer in England
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jtocrr.2021.100176
Publisher version: https://doi.org/10.1016/j.jtocrr.2021.100176
Language: English
Additional information: © 2021 The Authors. Published by Elsevier Inc. on behalf of the International Association for the Study of Lung Cancer. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Biomarkers, Mutation testing, Non–small cell lung cancer, Personalized medicine, Targeted therapy
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10142356
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