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Impact of the treatment of periodontitis on systemic health and quality of life: A systematic review

Orlandi, M; Muñoz Aguilera, E; Marletta, D; Petrie, A; Suvan, J; D'Aiuto, F; (2022) Impact of the treatment of periodontitis on systemic health and quality of life: A systematic review. Journal of Clinical Periodontology , 49 (S24) pp. 314-327. 10.1111/jcpe.13554. Green open access

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Abstract

AIM: To investigate the effect of treatment of periodontitis on systemic health outcomes, pregnancy complications, and associated quality of life. MATERIALS AND METHODS: Systematic electronic searches were conducted to identify randomized controlled trials with minimum 6-month follow-up and reporting on the outcomes of interest. Qualitative and quantitative analyses were performed as deemed suitable. RESULTS: Meta-analyses confirmed reductions of high-sensitivity C-reactive protein (hs-CRP) [0.56 mg/L, 95% confidence interval (CI) (−0.88, −0.25), p < .001]; interleukin (IL)-6 [0.48 pg/ml, 95% CI (−0.88, −0.08), p = .020], and plasma glucose [1.33 mmol/l, 95% CI (−2.41, −0.24), p = .016], and increase of flow-mediated dilation (FMD) [0.31%, 95% CI (0.07, 0.55), p = .012] and diastolic blood pressure [0.29 mmHg, 95% CI (0.10, 0.49), p = .003] 6 months after the treatment of periodontitis. A significant effect on preterm deliveries (<37 weeks) was observed [0.77 risk ratio, 95% CI (0.60, 0.98), p = .036]. Limited evidence was reported on quality-of-life (QoL) outcomes in the included studies. CONCLUSIONS: Treatment of periodontitis results in systemic health improvements including improvement in cardiometabolic risk, reduction in systemic inflammation and the occurrence of preterm deliveries. Further research is however warranted to confirm whether these changes are sustained over time. Further, appropriate QoL outcomes should be included in the study designs of future clinical trials.

Type: Article
Title: Impact of the treatment of periodontitis on systemic health and quality of life: A systematic review
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/jcpe.13554
Publisher version: https://doi.org/10.1111/jcpe.13554
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: inflammation, periodontitis, periodontal treatment, systemic health
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Restorative Dental Sciences
UCL > Provost and Vice Provost Offices > VP: Research > Library Services
URI: https://discovery.ucl.ac.uk/id/eprint/10142309
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