Chai, Y;
Luo, H;
Wei, Y;
Chan, SKW;
Man, KKC;
Yip, PSF;
Wong, I;
(2022)
Risk of self-harm or suicide associated with specific drug use disorders, 2004–2016: a population-based cohort study.
Addiction
10.1111/add.15820.
(In press).
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Abstract
BACKGROUND AND AIMS: Drug use disorders are associated with increased risk of self-harm. Risk differences associated with specific types of drug use disorders are yet to be comprehensively reported. This study aimed to examine the risk of self-harm or suicide associated with different drug use disorders in Hong Kong. DESIGN: Population-based cohort study. SETTING: The Clinical Data Analysis and Reporting System (CDARS) managed by the Hong Kong Hospital Authority. PARTICIPANTS: Cases were people ages 10 years or older who visited a hospital Accident and Emergency department between 1 January, 2004 and 31 December, 2016 with any of 10 specific drug use disorders (comprising opioid; ketamine; methamphetamine; sedative, hypnotic, or anxiolytic; amphetamine or related stimulant; cocaine; cannabis; hallucinogen; unspecified or other drug; and polydrug). Each case was matched with two controls, selected from a subset of people in CDARS sharing the same gender, age and psychiatric profile. A total of 8270 cases and 16 540 matched controls were included. MEASUREMENTS: Incidence and adjusted hazard ratio (aHR) of subsequent self-harm or suicide for each specific drug use disorder were estimated. FINDINGS: The most prevalent drug use disorder was opioid use disorder (2523; 30.51%) and the least prevalent was hallucinogen use disorder (77; 0.93%). The crude incidence of self-harm or suicide ranged from 26.57 (95% CI, 14.23–44.55) per 1000 person-years for cannabis use disorder to 91.97 (77.32–108.37) for polydrug use disorder. The highest risk of self-harm or suicide was observed in ketamine (aHR, 16.36; 95% CI, 11.03–24.29) and opioid (15.97; 10.73–23.23) use disorders. CONCLUSIONS: In Hong Kong, all types of drug use disorders appear to be significantly associated with increased risk of self-harm or suicide, but risk levels vary by type of drug use disorder.
| Type: | Article |
|---|---|
| Title: | Risk of self-harm or suicide associated with specific drug use disorders, 2004–2016: a population-based cohort study |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/add.15820 |
| Publisher version: | https://doi.org/10.1111/add.15820 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | CDARS, drug use disorders, Hong Kong, psychiatric disorders, self-harm, substance use disorders,suicide |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Practice and Policy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10142266 |
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