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Genome-Wide Association Study Identifies Two Common Loci Associated with Pigment Dispersion Syndrome/Pigmentary Glaucoma and Implicates Myopia in its Development

Simcoe, MJ; Shah, A; Fan, B; Choquet, H; Weisschuh, N; Waseem, NH; Jiang, C; ... Hammond, CJ; + view all (2022) Genome-Wide Association Study Identifies Two Common Loci Associated with Pigment Dispersion Syndrome/Pigmentary Glaucoma and Implicates Myopia in its Development. Ophthalmology , 129 (6) pp. 626-636. 10.1016/j.ophtha.2022.01.005. Green open access

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Abstract

Purpose – To identify genetic variants associated with pigment dispersion syndrome and pigmentary glaucoma in unrelated patients, and to further understand the genetic and potentially causal relationships between pigment dispersion syndrome and associated risk factors. // Design – A two-stage genome-wide association meta-analysis with replication and subsequent in-silico analyses including Mendelian randomisation. // Subjects – A total of 574 cases with pigmentary glaucoma and/or pigment dispersion syndrome and 52,627 controls of European descent. // Methods – Genome-wide association analyses were performed in four cohorts and meta-analysed in three stages: first a discovery meta-analysis of three cohorts, secondly replication was performed in the fourth cohort, thirdly all four cohorts were meta-analysed to increase statistical power. Two-sample Mendelian randomisation was utilised to determine whether refractive error and intraocular pressure exert causal effects over pigment dispersion syndrome. // Results – Significant association was present at two novel loci for pigment dispersion syndrome/pigmentary glaucoma. These loci and follow up analyses implicate the genes GSAP (lead SNP: rs9641220, p=6.0x10-10) and GRM5/TYR (lead SNP: rs661177, p=3.9x10-9) as important factors in disease risk. Mendelian randomisation showed significant evidence that negative refractive error (myopia) exerts a direct causal effect over pigment dispersion syndrome (p=8.9x10-7). // Main Outcome Measures – A) The association of genetic variants with pigment dispersion syndrome and, B) whether myopia exerts causal effects over pigment dispersion syndrome. // Conclusions – Common SNPs relating to the GSAP and GRM5/TYR genes are associated risk factors for the development of pigment dispersion syndrome and pigmentary glaucoma. Although myopia is a known risk factor, this study is the first to use genetic data to demonstrate that myopia is, in part, a cause of pigment dispersion syndrome and pigmentary glaucoma.

Type: Article
Title: Genome-Wide Association Study Identifies Two Common Loci Associated with Pigment Dispersion Syndrome/Pigmentary Glaucoma and Implicates Myopia in its Development
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ophtha.2022.01.005
Publisher version: https://doi.org/10.1016/j.ophtha.2022.01.005
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: GWAS, Mendelian randomization, Pigmentary glaucoma, Pigment dispersion syndrome
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10141836
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