UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

T cell phenotype in paediatric heart transplant recipients

Mengrelis, K; Kucera, F; Shahid, N; Watt, E; Ross, S; Lau, C-I; Adams, S; ... Davies, EG; + view all (2021) T cell phenotype in paediatric heart transplant recipients. Pediatric Transplantation , 25 (5) 10.1111/petr.13930. Green open access

[thumbnail of PDF38045572-780429769.pdf]
Preview
Text
PDF38045572-780429769.pdf - Accepted Version

Download (1MB) | Preview

Abstract

Paediatric heart transplantation recipients suffer an increased incidence of infectious, autoimmune and allergic problems. The relative roles of thymus excision and immunosuppressive treatments in contributing to these sequelae are not clear. We compared the immunological phenotypes of 25 heart transplant recipients (Tx), 10 children who underwent thymus excision during non-transplantation cardiac surgery (TE) and 25 age range–matched controls, in two age bands: 1-9 and 10-16 years. Significant differences from controls were seen mainly in the younger age band with Tx showing lower CD3 and CD4 cell counts whilst TE showed lower CD8 cell counts. Naïve T cell and recent thymic emigrant proportions and counts were significantly lower than controls in both groups in the lower age band. T cell recombination excision circle (TREC) levels were lower than controls in both groups in both age bands. There were no differences in regulatory T cells, but in those undergoing thymus excision in infancy, their proportions were higher in TE than Tx, a possible direct effect of immunosuppression. T cell receptor V beta spectratyping showed fewer peaks in both groups than in controls (predominantly in the older age band). Thymus excision in infancy was associated with lower CD8 cell counts and higher proportions of Tregs in TE compared to Tx. These data are consistent with thymus excision, particularly in infancy, being the most important influence on immunological phenotype after heart transplantation.

Type: Article
Title: T cell phenotype in paediatric heart transplant recipients
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/petr.13930
Publisher version: https://doi.org/10.1111/petr.13930
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: immune reconstitution; paediatric heart transplantation; T lymphocytes; thymectomy
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10141765
Downloads since deposit
187Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item