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How Do We Predict a Patient's Disease Course and Whether They Will Respond to Specific Treatments?

Verstockt, B; Parkes, M; Lee, J; (2022) How Do We Predict a Patient's Disease Course and Whether They Will Respond to Specific Treatments? Gastroenterology , 162 (5) pp. 1383-1395. 10.1053/j.gastro.2021.12.245. Green open access

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Abstract

Gastroenterologists will be all too familiar with the difficult decisions that managing IBD often presents. How aggressively should I treat this patient? Do I expect them to have a mild or aggressive form of disease? Do they need a biologic? If so, which one? And when should I start it? The reality is that the answers that would be right for one patient might be disastrous for another. The growing therapeutic armamentarium will only make these decisions more difficult, and yet we have seen how other specialties have begun to use the molecular heterogeneity in their diseases to provide some answers. In this article, we review the progress that has been made in predicting the future for any given IBD patient – whether that is the course of disease that they will experience or whether or not they will respond to, or indeed tolerate, a particular therapy.

Type: Article
Title: How Do We Predict a Patient's Disease Course and Whether They Will Respond to Specific Treatments?
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1053/j.gastro.2021.12.245
Publisher version: https://doi.org/10.1053/j.gastro.2021.12.245
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: biomarkers, inflammatory bowel diseases, precision, prediction, prognosis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: https://discovery.ucl.ac.uk/id/eprint/10141750
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