Zaman, S;
Kane, T;
Katta, M;
Georgiou, M;
Michaelides, M;
(2021)
Photoaversion in inherited retinal diseases: clinical phenotypes, biological basis, and qualitative and quantitative assessment.
Ophthalmic Genetics
10.1080/13816810.2021.2015789.
(In press).
Preview |
Text
Photoaversion in inherited retinal diseases clinical phenotypes biological basis and qualitative and quantitative assessment.pdf - Published Version Download (1MB) | Preview |
Abstract
Severe light sensitivity is a feature common to a range of ophthalmological and neurological diseases. In inherited retinal diseases (IRDs) particularly, this may be accompanied by significant visual disruption. These symptoms are extremely debilitating for affected individuals and have significant implications in terms of day-to-day activities. Underlying mechanisms remain to be fully elucidated. Currently, there are many assessments of photoaversion (PA), however, all have limitations, with quantitative measurement in particular needing further evaluation. To understand the complexities associated with photoaversion from different pathologies, qualitative and quantitative assessments of the light aversion response must be standardized. There is no treatment to date, and strategies to alleviate symptoms focus on light avoidance. With respect to IRDs, however, gene therapy is currently being investigated in clinical trials and promising and further treatments may be on the horizon. The better characterization of these symptoms is an important end point measure in IRD gene therapy trials.
Type: | Article |
---|---|
Title: | Photoaversion in inherited retinal diseases: clinical phenotypes, biological basis, and qualitative and quantitative assessment |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1080/13816810.2021.2015789 |
Publisher version: | https://doi.org/10.1080/13816810.2021.2015789 |
Language: | English |
Additional information: | © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Ophthalmology, Photoallodynia, photoaversion, photophobia, photosensitivity, light sensitivity, genetics, inherited retinal disease, quality of life, endpoints, LINKED CONE DYSFUNCTION, GANGLION-CELLS, UNANSWERED QUESTIONS, ESSENTIAL BLEPHAROSPASM, VISUAL PATHWAY, CONTACT-LENSES, PHOTOPHOBIA, LIGHT, HEADACHE, PHOTOSENSITIVITY |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
URI: | https://discovery.ucl.ac.uk/id/eprint/10141703 |
Archive Staff Only
![]() |
View Item |