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Adhesion Molecule Targeted Therapy for Non-Infectious Uveitis

Chen, YH; Lightman, S; Eskandarpour, M; Calder, VL; (2022) Adhesion Molecule Targeted Therapy for Non-Infectious Uveitis. International Journal of Molecular Sciences , 23 (1) , Article 503. 10.3390/ijms23010503. Green open access

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Abstract

Non-infectious uveitis (NIU) is an inflammatory eye disease initiated via CD4+ T-cell activation and transmigration, resulting in focal retinal tissue damage and visual acuity disturbance. Cell adhesion molecules (CAMs) are activated during the inflammatory process to facilitate the leukocyte recruitment cascade. Our review focused on CAM-targeted therapies in experimental autoimmune uveitis (EAU) and NIU. We concluded that CAM-based therapies have demonstrated benefits for controlling EAU severity with decreases in immune cell migration, especially via ICAM-1/LFA-1 and VCAM-1/VLA-4 (integrin) pathways. P-selectin and E-selectin are more involved specifically in uveitis related to vasculitis. These therapies have potential clinical applications for the development of a more personalized and specific treatment. Localized therapies are the future direction to avoid serious systemic side effects.

Type: Article
Title: Adhesion Molecule Targeted Therapy for Non-Infectious Uveitis
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/ijms23010503
Publisher version: https://doi.org/10.3390/ijms23010503
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Adhesion molecule; integrin; lymphocyte function-associated antigen-1 (LFA-1); very late antigen-4 (VLA-4); uveitis; experimental autoimmune uveitis; non-infectious uveitis; intercellular cell adhesion molecule-1 (ICAM-1); vascular cell adhesion protein 1 (VCAM-1); selectin
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10141671
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