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Different rates of cognitive decline in autosomal dominant and late-onset Alzheimer disease

Buckles, VD; Xiong, C; Bateman, RJ; Hassenstab, J; Allegri, R; Berman, SB; Chhatwal, JP; ... Dominantly Inherited Alzheimer's Network; + view all (2021) Different rates of cognitive decline in autosomal dominant and late-onset Alzheimer disease. Alzheimer's & Dementia 10.1002/alz.12505. (In press).

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Abstract

As prevention trials advance with autosomal dominant Alzheimer disease (ADAD) participants, understanding the similarities and differences between ADAD and "sporadic" late-onset AD (LOAD) is critical to determine generalizability of findings between these cohorts. Cognitive trajectories of ADAD mutation carriers (MCs) and autopsy-confirmed LOAD individuals were compared to address this question. Longitudinal rates of change on cognitive measures were compared in ADAD MCs (n = 310) and autopsy-confirmed LOAD participants (n = 163) before and after symptom onset (estimated/observed). LOAD participants declined more rapidly in the presymptomatic (preclinical) period and performed more poorly at symptom onset than ADAD participants on a cognitive composite. After symptom onset, however, the younger ADAD MCs declined more rapidly. The similar but not identical cognitive trajectories (declining but at different rates) for ADAD and LOAD suggest common AD pathologies but with some differences.

Type: Article
Title: Different rates of cognitive decline in autosomal dominant and late-onset Alzheimer disease
Location: United States
DOI: 10.1002/alz.12505
Publisher version: https://doi.org/10.1002/alz.12505
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Alzheimer disease, autosomal dominant Alzheimer disease, cognitive, comorbidities, late-onset Alzheimer disease
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10141384
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